Pro-Argin™ Technology Mode Of Action


Hypersensitivity and exposed dentin tubules

Dentin hypersensitivity occurs when dentin becomes exposed and tubules are open at the dentin surface. Gingival recession is the primary way dentin is exposed in the cervical region of the tooth. Once the root is exposed, the protective layer of cementum is easily removed, resulting in open dentin tubules. Dentin hypersensitivity affects up to 57% of patients.1

Tooth Anatomy

Fluid disturbances within dentin tubules

Based on Brännström's Hydrodynamic Theory,2,3 dentin hypersensitivity is caused by movement of fluid in open dentin tubules. Heat, cold, air and pressure can cause this rapid movement of fluid in open dentin tubules.

Fluid Disturbances Within Dentin Tubules

How pain occurs

Each of these stimuli produces a movement or disturbance of fluid in the dentin tubule (as shown by the arrows in the illustration). This change in fluid flow causes a pressure change within the dentin, which activates the intradental nerves causing a signal that is interpreted as pain.1

How Pain Occurs

Introducing Pro-ArginTM/MC Technology for Sensitivity Relief

Pro-ArginTM/MC Technology contains arginine, an amino acid naturally found in saliva, and calcium carbonate

Research has revealed that arginine provides naturally protective oral health benefits.5,6 Colgate has harnessed this knowledge and added Pro-ArginTM/MC Technology, consisting of arginine and calcium carbonate, to oral care products to deliver proven sensitivity relief benefits.

How Pro-ArginTM/MC Technology Occludes Tubules

Latest research suggests that at physiological pH, arginine and calcium carbonate interact and bind to the negatively charged dentin surface to form a calcium rich layer on the dentin surface and in the dentin tubules to plug and seal them.

How Pro-Argin<sup>TM/MC</sup> Technology Occludes Tubules

How Pro-ArginTM/MC Technology Blocks Pain

Pro-ArginTM/MC Technology triggers an occlusion of the dentin tubules that remains intact even after exposure to acids, preventing transmission of painproducing stimuli.

How Pro-Argin<sup>TM/MC</sup> Technology Blocks Pain


Clinically Proven to Deliver Instant and Lasting Sensitivity Relief for 4 Weeks After a Single Application

8% arginine Technology Desensitising Prophylaxis Paste vs. Negative Control: Pumice Fluoride-free Prophylaxis Paste

Hydraulic Conductance Test


1 Addy M. Dentin hypersensitivity: new perspectives on an old problem. Int Dent J. 2002;52(Suppl 5):3367-3375

2 Brännström M. A hydrodynamic mechanism in the transmission of pain-produced stimuli through the dentin. In: Sensory Mechanisms in Dentin. Anderson DJ, ed. pp 73-79. Pergamon Press. London, 1963.

3 Brännström M., Johnson G. Movements of the dentin and pulp liquids on application of thermal stimuli. Acta Odontol Scand. 1970;28:59-70.

4 Data on file, Colgate-Palmolive, 2008.

5 Kleinberg I. A new saliva based anti-caries composition. Dent Today. 1999;18:98-103.

6 Kleinberg I. Sensistat: A new saliva based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today. 2002;21:42-47.

Important Safety Information: Colgate* Sensitive Pro-ReliefTM/MC is a desensitizing paste that should only be administered by individuals professionally trained to perform dental prophylaxis. It may cause eye irritation upon contact and is contraindicated in patients with a known allergy to any of the components.